why is my nipt test inconclusive

I am very curious in your case of you are mosaic Turner yourself, have you had any issues with growth? MaterniT21 positive for Down Syndrome. Patients having this testing should know that NIPT results do not diagnose a genetic condition or give a yes/no answer, and should seek follow-up testing if appropriate. The fetal fraction may be lower earlier in the pregnancy, and sometimes we may see a lower fetal fraction when a woman has a higher maternal weight, but not always. NIPT analyzes the mother's blood to assess the genetic makeup of a fetus . Thanks, I'm still waiting! . Some radiologists like to comment on ALL the scans the technicians provided even the poor quality ones. They said I can get retested and said maybe cause blood had to fly from nz to au? Thank you for sharing your personal story with me. When this happens, the testing companies would rather report and inconclusive than a wrong result. Had my harmony test at 10 weeks 3 days. This occurs about 1 in every 150-200 samples. First, conventional screening methods which . After hearing so many inconclusive NIPT results or issues do you know if there is another option/testing I can request? Hope you get some answers soon. The second test was done at 11 weeks. It actually doesn't stay in your system that long. My NIPT came up inconclusive the first time as well. Show your support by. to help the technology advance more with this newer test. Look up their websites and they will tell you the disorders they test for and the accuracy. They told me there wasn't enough fetal DNA in my blood to accurately complete the test. Getting my blood redrawn tomorrow. Half of my cells are missing an X chromosome so it didnt manifest itself too clinically with me and I knew nothing of it for 35 years. These assays provide information that is not available from histological examination, and can help guide diagnosis, therapy, and monitoring of disease. It's a screening test offered during pregnancy to see if the fetus is at risk for having a chromosomal disorder like Down syndrome (trisomy 21), trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome). What Can NIPT Tell You? No, NIPT is a screening test, not a diagnostic test. Thanks for sticking with us for a full year. As of now I have no cardiac or kidney problems but I will see specialists when this baby is born just to be sure. Just wondering if anyone has been through something similar :( thanks. Update: I did the redraw and got my results back yesterday. I was just so surprised to get an "inconclusive" a second time- the woman in the lab who drew my blood said she had never seen it come back that way twice! Community for those with abnormal or discordant Noninvasive Prenatal Testing (NIPT/NIPS) screening results: FALSE POSITIVE, FALSE NEGATIVE, TRUE POSITIVE & those stuck in limbo. Some disadvantages, or risks, that come from genetic testing can include: Testing may increase your stress and anxiety. This time they were able. Please guide us. I'll do my 3rd test at nearly 16 weeks. I hope this helps you consider an alternative, less stressful reason. Im currently going through the exact same thing. Keep us posted! Lastly, the information in this post is intended for you to be able to read up on what may be happening, have these studies available to you so you can better discuss this situation and your options with your maternal fetal medicine doctor and a GOOD genetic counselor. Everything came back low risk, so relieved and thankful. Not to scare you, but the other reason it can happen is if the result is borderline close to positive. But yes anyway, I'm sure it will all be fine. Lastly, if it is a twin pregnancy, then it would again be difficult to attain a proper conclusion for the NIPT test. It was terrifiying, to say the least. GAH! My advice: dont look at it. Inconclusive NIPT results. Not even gender. Thanks for sharing your story! Hey there, thank you for visiting the sub. It was determined that most likely I was missing partial or all X chromosomes (monosomy x, also know as Turner syndrome) but we couldnt be 100% it wasnt the baby without doing an amnio and a karyotype blood test on me. These are in different colors and allows users to actually click on the post flair and pull up every post that has a similar situation such as -no results-trisomy 13-NT scan question-etc. We are repeating the assay on the same sample you have already sent and we should have that result on Wednesday. This is so when you speak to others, they immediately understand your situation AND you can see their situation summary. I will keep you all informed about this issue. 20052023 BabyCenter, LLC, a Ziff Davis company. It has to be at least above 4 percent to give a conclusive result. I'm grateful insurance pays for both. In some cases, a test result might not give any useful information. Certain prenatal screening tests like NIPT are very accurate for conditions such as Down syndrome, but less so for rare genetic conditions. But how often do these tests fail to provide results, and what might such a result mean? I needed a NIPT done as there were MANY concerns on my 20 week ultrasound. My fetal fraction on 2nd try was only 2.7% :( 3.8% sounds good! We had a false positive on one of our screens with our first and had to wait 3 weeks before we could do the next round of testing (had to be 18+ weeks and we weren't that far along). What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. harry hill family. Went back yesterday and did a redraw, and now I'm hoping this one takes. The non-invasive prenatal test (NIPT) is an accurate screening test for common trisomies, sex chromosome aneuploidies and other selected chromosome abnormalities. The Sonic Education website has been developed to serve as an easy-to-navigate online learning platform. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Did you opt for an amnio? Im 20 years old Microarray (rare duplication? This is unlikely to be a lab mistake. Start by selecting which of these best describes you! However my 12 weeks nt scan and efts blood test both came back normal/ low risk for down syndrome at 1/10000. I'm panicking now because I'm so worried. It definitely makes me feel better with whatever the outcome may be. I know i'm not really that "old" at 35, I guess it's also cos lots of friends around me did the test who are around the same age as me and all recommended it. This is the route I took with my son (now 4.5) so I'm familiar with it. Now Im seeing that inconclusive results are associated with a higher risk of chromosomal issues as well as GD and preeclampsia. NIPT is most often used to screen for trisomy. why is my nipt test inconclusive. Edited to add: discussed further with the midwife, low fetal fraction was the reason for inconclusive results I met with a genetic counsellor who reviewed my file, age and risk, nd we decided together no further testing was needdd however for peace of mind and funsies we did the quad test which is a hormone test and can flag for trisonmies. Had my redraw at 13+2, and results have come back the same . Please read top 2 pinned posts & automod message for information about the screen and your result. They said there wasn't enough fetal DNA but I had my blood drawn at about 10.5 weeks and then 12 weeks and it was still inconclusive! On the report, this is called a "low fetal fraction". Not to scare you, but the other reason it can happen is if the result is borderline close to positive. I'm not sure how that works, but it doesn't necessarily indicate a problem. And with this one the baby is only 1mm over the normal rate in both kidneys and a bright spot on the heart. Find advice, support and good company (and some stuff just for fun). We went with Myriad. I am booked for a 12 week scan this week. Same happened to us. Both of these usually go away but I'm just worried! I just opted to the NIPT at the same time I did the EFTS, as I have heard that there can be lots of false positives due to different factors including age. I appreciate those who chime in as we all remember how difficult to be in this situation. But I'm still a nervous wreck! (High HCG, low PAAP-A, normal nuchal translucency.) think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. All rights reserved. It has to be at least above 4 percent to give a conclusive result. Hi there new to this board ( been hanging out on my month board and just found this one ). We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. My EFT done at 13weeks came high risk and did NIPT around 15 weeks (harmony) results came back after a week with extreme low risk. However, the NT screens for things other than Down's. Clicking on the green -no result post flair- will bring up everyone who has also tagged their submission as no results/low fetal fractions and you can read up their stories/outcomes and responses (or any other topic that is common for NIPT results. Our commitment to quality means that we will only provide a result when there is very clear evidence for, or against, the presence of a specific disorder. The test can also determine the sex of the fetus. and mine came back at 3.7% and couldn't be read. I actually have an auto immune disease so they think thats why. Archived discussions are usually a bit older and not as active as other community content. Ive been referred to edmonton fetal medicine not so much because they are worried but more because NIPT is new and finding out why we get inclonclusive results would help the technology advance more. To help you get started read our. Apart from these two reasons, there are a plethora of factors that can contribute to an inconclusive result. We strive to provide you with a high quality community experience. thank you for sharing your story. My NIPT came up inconclusive the first time as well. The most common reason for NIPT failures is that the blood sample did not have enough genetic material (DNA) from the pregnancy. Seems unfair to leave you in limbo not knowing. Apparently you are able to conceive, so maybe being mosaic is not that bad after all? I hope the baby is growing healthy. POSITIVE PREDICTIVE VALUE CALCULATOR FOR NIPT RESULTS https://www.perinatalquality.org/Vendors/NSGC/NIPT/, *I highly suggest you first read through everything in main post located here to start: https://www.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, *After this head over to this post about the actual individual results: https://www.reddit.com/r/NIPT/comments/itmyjw/my_nipt_results_show_this_abnormality_what_does/. Just tonight I found out the second draw of blood for the Harmony. I think in my case, my first test must have been borderline. I had my blood drawn for the NIPT test on 12/28. This was simply a technical issue within the laboratory. Sorry youve gone through this stress xx. I was told I was high risk for everything and just now have to suffer and wait for my CVS. My ex husband and I struggled to conceive for years. My OB was only going to recommend NIPT if there was something high risk on the regular screening, I was just a tad inpatient and went for the testing right away (and also wanted to know the gender). 20052023 BabyCenter, LLC, a Ziff Davis company. At 10 weeks, I undertook the harmony test, it came back as inconclusive, I didn't know why as my dr was on holidays but was told by the lab to go back and get a redraw, which did 6 days after the first initial test. sm1232, did you receive your results? Possible reasons for this include: Timing of blood draw - there is a higher chance for the test to fail when the blood draw is done too early in the pregnancy, 127 BPM! So sorry youre having to deal with this, and having to sit with this anxiety a bit longer. So sorry to hear that! It's my understanding that while they both screen for Down's, the NT provides information on "soft" markers. how to find the length of an oval track; how long to cook baked potato on grill; george pearsons house; distance from thunder bay to manitoba border I just got inconclusive results too!!! SMFM 2015: A failed result on noninvasive prenatal testing (NIPT) may provide insight into what subsequent tests may find, research reveals. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Mine should** be in tomorrow or Friday. I wouldn't bet on the NT measurements to guide you. Use of this site is subject to our terms of use and privacy policy. We are going to have an amnio in coming week as per the genetic councellor suggested us to see what is that coming in NIPT and ultrasound scan..I have also a scan scheduled at week 18 to see if Godforbid is any serious abnormality so we can terminate. Hi bubblegum, I am in the same situation and am having a retest next week. I had two test come bck with not enough fetal dna was very worried as the year before same thing had happened with nipt but bubs ended up having t18 so first instinct was it's happening again but this time I was on blood thinners due to dvt from covid and being intubated for 7 days my dr told me not to be worried as my morph scan came bck fine no abnormalities were found in scan and measurements were all In normal range this was at 14 weeks had my scan at 19 weeks and bubs is doing fine everything is ok unless you have comme bck high risk I yhink nipt test are just stressful I'm now currently 24 plus2 and everything is going well God willing I hope this gives you some comfort have faith and hope all the best, Meet other parents of September 2018 babies and share the joys and challenges as your children grow. So sorry to hear this is your experience. :). Please whitelist our site to get all the best deals and offers from our partners. (1/19). haha our timing for the tests sound quite similar, i am waiting for the referral to see the genetic counselor, so for now will have to wait and see what they recommend. I have found this NIPT thing to be a major stressor and not sure I would do it again in another pregnancy, but feel I am so far along the process this time lol. I've read online it could happen to plus size moms? ), confined to placenta (best case) or the baby, and it being a boy potentially missing an X chromosome had all the professionals baffled. It lead to 3 weeks of PURE hell. I just got referred to McMaster as well with a high risk FTS scan/blood work. Information on `` soft '' markers weeks 6 days the core values of the brand by reporting content that the... Back yesterday and did a redraw, and can help guide diagnosis, therapy, and now i no. With growth enough fetal DNA in my case, my first test have. 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